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        Live Knockout Mice & Conditional Knockout Mice

        GemPharmatech's ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields, including oncology, autoimmunity, metabolism, and neurodegeneration. we have created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing for nearly unlimited genetic combinations to fit your research objectives.

        We offer live mice for featured strains to save time for breeding and resuscitation, which can greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date and is first come, first served.


        Benefits:

        • Live mice in stock and ready to ship in as soon as two weeks

        • Largest collection of gene editing mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.

        • Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.


        In-stock List (valid through May 10th, 2024)

        KO & cKO Mice

        Strain ID

        Targeted Gene

        Background

        Genotype

        Application

        T012747

        Sting1C57BL/6JGptHomozygousViral infections, innate Immunity, autoimmunity, cellular stress and autophagy

        T010873

        Nlrp3C57BL/6JGptHomozygousInnate immunity, inflammatory response

        T005534

        Ifnar1C57BL/6JGptHomozygousViral infection, inflammatory response, oncology-immunity
        T009945Cpt1aC57BL/6JGptHeterozygousMetabolic research, developmental biology, cardiovascular system, nervous system, signal transduction, vision/eye, reproductive system, mitochondrial research, physiological system, homeostasis/metabolism, cell biology, molecular biology, cellular, mortality/aging, cell localization, lipid metabolism, cytomembrane, transferase
        T012963Spp1C57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,cardiovascular system,skeleton,Muscle ,respiratory system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell death,cellular,Cell localization,Golgi apparatus,Molecular biology,Signal Transduction,DNA transcription
        T006659mettl3C57BL/6JGptHomozygousMetabolic research,Protein metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,Cell biology,cell nucleus,Molecular biology,Signal Transduction,RNA binding protein,transferase
        T011901Aqp4C57BL/6JGptHeterozygousMetabolic research,Developmental Biology,immune system,cardiovascular system,nervous system,vision/eye,hearing/ear,renal/urinary system,Physiological system,homeostasis/metabolism,behavior/neurological,Cell biology,Molecular biology,cellular,hematopoietic system,mortality/aging,Cell localization,Cytoplasmic vesicle,endosome,Organelles membrane,transporter
        T052308Adrb2C57BL/6JGptHomozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,immune system,nervous system,vision/eye,synapse,Physiological system,cardiovascular system,skeleton,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Cytoplasmic vesicle,endosome,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription
        T019676Zbp1-floxC57BL/6JGptHeterozygousImmune system,Cell biology,cellular,cell nucleus,Molecular biology,Signal Transduction,DNA binding protein
        T011518Pf4C57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Developmental Biology,cell differentiation,Physiological system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cytoplasmic vesicle,Molecular biology,Signal Transduction,DNA transcription
        T011862Gdf15C57BL/6JGptHeterozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,nervous system,behavior/neurological,Physiological system,cardiovascular system,renal/urinary system,hematopoietic system,Cell biology,cellular,Golgi apparatus,cell nucleus,Molecular biology,Signal Transduction,DNA transcription
        T050579Sirt3C57BL/6JGptHeterozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,growth/size/body,immune system,nervous system,behavior/neurological,Physiological system,cardiovascular system,skeleton,digestive/alimentary system,liver/biliary system,Cell biology,Mitochondrial research,cellular,Cell localization,cell nucleus,cytomembrane,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein,hydrolytic enzyme,transferase
        T052325Fto-floxC57BL/6JGptHeterozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,nervous system,behavior/neurological,Physiological system,integument,skeleton,renal/urinary system,Cell biology,Cell Proliferation,cell nucleus,Molecular biology,oxidordeuctase
        T005857Adrb1C57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Developmental Biology,cell differentiation,mortality/aging,nervous system,synapse,Physiological system,cardiovascular system,Cell biology,Cell death,cellular,Cell localization,Cytoplasmic vesicle,endosome,cell nucleus,Organelles membrane,Molecular biology,Signal Transduction
        T006658Sirt3C57BL/6JGptHeterozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,growth/size/body,immune system,nervous system,behavior/neurological,Physiological system,cardiovascular system,skeleton,digestive/alimentary system,liver/biliary system,Cell biology,Mitochondrial research,cellular,Cell localization,cell nucleus,cytomembrane,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein,hydrolytic enzyme,transferase
        T009161ArntlC57BL/6JGptHeterozygousMetabolic research,Developmental Biology,immune system,integument,cardiovascular system,nervous system,Circadian Rhythms,Signal Transduction,skeleton,vision/eye,Muscle ,respiratory system,adipose tissue,DNA transcription,reproductive system,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,Cell biology,Molecular biology,cellular,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,Cell localization,cell nucleus,DNA binding protein
        T012501ClockC57BL/6JGptHeterozygousMetabolic research,Developmental Biology,integument,cardiovascular system,nervous system,Signal Transduction,adipose tissue,DNA transcription,reproductive system,digestive/alimentary system,Protein metabolism,liver/biliary system,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,Cell biology,Molecular biology,cellular,growth/size/body,Cell localization,endoplasmic reticulum,cell nucleus,DNA binding protein,transferase
        T028509Mbl2C57BL/6JGptHeterozygousDevelopmental Biology,skeleton,Physiological system,cell differentiation,Cell biology,Molecular biology,limbs/digits/tail,Cell localization,Lipid binding protein
        T011654
        Ido1C57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Developmental Biology,immune system,Physiological system,cardiovascular system,Muscle ,reproductive system,renal/urinary system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Molecular biology,oxidordeuctase
        T052181Foxa2C57BL/6JGptHeterozygousMetabolic research,adipose tissue,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,immune system,nervous system,vision/eye,behavior/neurological,Physiological system,integument,cardiovascular system,skeleton,craniofacial ,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,endocrine/exocrine glands,hematopoietic system,Cell biology,cellular,Cell localization,cell nucleus,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein
        T064052Spp1-KOC57BL/6JGptHeterozygoushomeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,integument,cardiovascular system,skeleton,Muscle ,respiratory system,liver/biliary system,renal/urinary system,hematopoietic system,Cell death,cellular,Cell localization,Golgi apparatus,Signal Transduction,DNA transcription


        Cre Mice

        Strain ID

        Targeted Gene

        Background

        Genotype

        Application

        T004714

        H11-Vil1-iCre-ployAC57BL/6JGptHomozygousTheoretically labeled cell type: gut epithelial cells

        T050182

        Rosa26-SA-CreERT2C57BL/6JGptHomozygousExpression system/tissue: whole body (low activity in brain and skeletal muscle)

        T004818

        Cd4-iCreC57BL/6JGptHomozygousTheoretically labeled cell type: Helper T cells (CD4+ T cells)
        T010829Tg(Prox1-CreERT2)C57BL/6JGptHeterozygousTool mice, Cre/Dre, immune system

        T006768

        Cx3cr1-iCreC57BL/6JGptHomozygous

        Expressed system/tissue: immune system (see strain information for details);

        Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; 

        No cellular level validation performed.

        T050183

        Rosa26-EIIA-iCreC57BL/6JGptHeterozygous

        Expressed system/tissue: systemic (see strain information for details);

        Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); 

        No cellular level validation performed.

        T004829H11-Vil1-CreERT2-ployAC57BL/6JGptHeterozygousTool mice, Cre/Dre, physiological system, digestive/alimentary system
        T006205Lrat-P2A-iCreC57BL/6JGptHomozygousTheoretically labeled cell type: hepatic stellate cells
        T052686Cdh5-P2A-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
        T006806Myf5-P2A-iCreC57BL/6JGptHeterozygousTool mice, Cre/Dre
        T006589S100a4-CreERT2-PolyAC57BL/6JGptHeterozygousTool mice
        T005636H11-S100a8 (MRP8)-iCreC57BL/6JGptHeterozygousTool mice, Cre/Dre, immune system
        T006950H11-Ctsk-iCreC57BL/6JGptHomozygousMetabolic research, adipose tissue, tool mice, Cre/Dre, physiological system, skeleton, muscle 
        T050766Tmem119-P2A-CreERT2C57BL/6JGptHeterozygousTool mice, Cre/Dre, nervous system
        T004819H11-Itgax-iCreC57BL/6JGptHeterozygousCre/Dre,Tool Mice,immune system
        T004857H11-Gfap-iCreC57BL/6JGptHomozygousCre/Dre,Tool Mice,nervous system
        T006862Tagln-iCreC57BL/6JGptHomozygousCre/Dre,Tool Mice,cardiovascular system,Physiological system
        T052699H11-Syn1-iCreC57BL/6JGptHomozygousCre/Dre,Tool Mice,nervous system
        T058417H11-CAG-LSL-tdTomatoC57BL/6JGptHomozygousTool Mice,Fluorescent protein-labeled mouse,Systemic expression of instrumental proteins,Reporter Mice
        T004833H11-hKRT14-iCreC57BL/6JGptHeterozygousCre/Dre,Tool Mice,integument,Physiological system
        T005328Pf4-P2A-iCreC57BL/6JGptHeterozygousCre/Dre,Tool Mice,immune system
        T007005Cd8a-iCreC57BL/6JGptHeterozygousTool Mice,Cre/Dre,immune system
        T055339Tagln-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T005680H11-Nphs1-iCreC57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T007046Cdh16-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T036743Tg(Acta2-iCre)C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T052676Vav1-iCreC57BL/6JGptHomozygousTool Mice,Cre/Dre
        T052693Aldh1l1-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T052695Pdgfrb-P2A-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T006955Slc6a3-iCreC57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T017784H11-Alb-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T053779Postn-MerCreMerC57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T036859Tg(Ckmm-iCre)C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T049832Spp1-CreERT2-IRES-EGFPC57BL/6JGptHomozygousTool Mice,Cre/Dre
        T050180Nes-P2A-iCreC57BL/6JGptHomozygousTool Mice,Cre/Dre
        T052679Tg(Adipoq-CreERT2)C57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T005640Csf1r-IRES-iCreC57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T005674Ncr1-iCre-P2AC57BL/6JGptHeterozygousTool Mice,Cre/Dre
        T050132Phox2b-CreERT2C57BL/6JGptHeterozygousTool Mice,Cre/Dre


        Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.