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        Syngeneic Cell Lines

        GemPharmatech has an extensive collection of syngeneic cell lines, including murine-derived cells and genetic modification of the corresponding cells, as well as several popular target cells, including PDL1, CD47, CD73, CD19, CD20, CD33, EGFR, HER2, BCMA, etc., providing a rich resource of tumor models for immune checkpoint drug efficacy evaluation.


        Cancer TypeCell LineBackgroundEngineered Human or Mouse TargetAvailability
        ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)Available
        ColorectalCT26BALB/chCD47 (Tg)-mCD47(KO)Available
        ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD47(Tg)-mCD47(KO) Available  
        ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD73(Tg)-mCD73(KO) Available
        ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD39(Tg)-mCD39(KO)Available
        ColorectalCT26BALB/chNectin4 (Tg)-mNectin4(KO)Available
        ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hB7H3(Tg)-mB7H3(KO)Available
        ColorectalCT26BALB/chROR1(Tg)-mROR1(KO)Available
        ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available  (Cell only)
        ColorectalCT26BALB/chCD47(Tg)-mCD47(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available  (Cell only)
        ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)Available
        ColorectalMC38C57BL/6hCD47 (Tg)-mCD47(KO)Available
        ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)-hCD73(Tg)-mCD73(KO) Available
        ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)-hB7H3(Tg)-mB7H3(KO)Available
        ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available  (Cell only)
        ColorectalMC38C57BL/6hCD47(Tg)-mCD47(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available  (Cell only)
        BreastEMT6BALB/chPDL1(Tg)-mPDL1(KO)Available 
        BreastEMT6BALB/chCD39(Tg)-mCD39(KO)Available
        MelanomaB16F10C57BL/6hPDL1(Tg)-mPDL1(KO)Available
        LiverH22BALB/chPDL1(Tg)-mPDL1(KO)-hCD47(Tg)-mCD47(KO) Available
        LiverH22BALB/chPDL1(Tg)-mPDL1(KO) 
        ColorectalCT26 BALB/cNoneAvailable
        LiverH22BALB/cNoneAvailable
        Breast4T1BALB/cNoneAvailable
        BreastEMT6BALB/cNoneAvailable
        LymphomaA20BALB/cNoneAvailable
        LymphomaMPC-11BALB/cNoneAvailable
        LymphomaJ558BALB/cNoneAvailable
        B lymphocyteBcL1 clone 5B1bBALB/cNoneAvailable
        RenalRENCABALB/cNoneAvailable
        LeukemiaWEHI-3BALB/cNoneAvailable
        Embryonal CarcinomaNFPEBALB/cNoneAvailable
        ColorectalMC38 C57BL/6NoneAvailable
        LungLLC1 C57BL/6NoneAvailable
        PancreasPAN02 C57BL/6NoneAvailable
        MelanomaB16F0C57BL/6NoneAvailable
        MelanomaB16F1C57BL/6NoneAvailable
        MelanomaB16F10C57BL/6NoneAvailable
        BreastMMT 060562C57BL/6NoneAvailable
        BreastE0771C57BL/6NoneAvailable
        LymphomaYAC-1C57BL/6NoneAvailable
        LymphomaE.G7-OVAC57BL/6NoneAvailable
        LymphoblastC1498C57BL/6NoneAvailable
        B lymphocyteHOPC 1F/12C57BL/6NoneAvailable
        ProstateRM-1C57BL/6NoneAvailable
        SarcomaSaI/NTBDNoneAvailable
        BladderMB49TBDNoneAvailable


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